Role of Ly49 Receptors on Natural Killer Cells During Influenza Virus Infection

FieldValue
dc.contributor.authorMahmoud, Ahmad
dc.date.accessioned2012-08-23T19:22:20Z
dc.date.available2012-08-23T19:22:20Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/23192
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5940
dc.description.abstractNatural killer (NK) cells are lymphocytes of the innate immune system that play a major role in the destruction of both tumours and virally-infected cells. The cytotoxicity of NK cells is tightly controlled by signals received through activating and inhibitory receptors. NK cells express a variety of inhibitory receptors such as Ly49 receptors. Ly49 receptors bind to class I MHC molecules that expressed on normal cells. Using Ly49-deficient (NKCKD) mice we show that Ly49-KD NK cells successfully recognize and kill influenza virus-infected cells and that NKCKD mice exhibit better survival than wild-type mice. Moreover, influenza virus infection has a propensity to upregulate cell surface expression of MHC-I on murine lung epithelial cells in vivo. Significantly, we demonstrate increased lung damage of WT-mice versus NKCKD mice after influenza virus infection as determined by histological analyses. This data indicated that absence of Ly49 inhibitory NK receptors greatly enhances survival of infected mice.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectInfluenza Virus
dc.subjectMHC-I
dc.subjectNatural Killer cells
dc.subjectNK cells
dc.titleRole of Ly49 Receptors on Natural Killer Cells During Influenza Virus Infection
dc.typeThesis
dc.faculty.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
dc.contributor.supervisorMakrigiannis, Andrew
dc.embargo.termsimmediate
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentBiochimie, microbiologie et immunologie / Biochemistry, Microbiology and Immunology
CollectionThèses, 2011 - // Theses, 2011 -

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