Use of Systems Biology in Deciphering Mode of Action and Predicting Potentially Adverse Health Outcomes of Nanoparticle Exposure, Using Carbon Black as a Model

FieldValue
dc.contributor.authorBourdon, Julie A.
dc.date.accessioned2012-07-26T07:40:12Z
dc.date.available2012-07-26T07:40:12Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/23105
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5282
dc.description.abstractNanoparticles (particles less than 100 nm in at least one dimension) exhibit chemical properties that differ from their bulk counterparts. Furthermore, they exhibit increased potential for systemic toxicities due to their deposition deep within pulmonary tissue upon inhalation. Thus, standard regulatory assays alone may not always be appropriate for evaluation of their full spectrum of toxicity. Systems biology (e.g., the study of molecular processes to describe a system as a whole) has emerged as a powerful platform proposed to provide insight in potential hazard, mode of action and human disease relevance. This work makes use of systems biology to characterize carbon black nanoparticle-induced toxicities in pulmonary and extra-pulmonary tissues (i.e., liver and heart) in mice over dose and time. This includes investigations of gene expression profiles, microRNA expression profiles, tissue-specific phenotypes and plasma proteins. The data are discussed in the context of potential use in human health risk assessment. In general, the work provides an example of how toxicogenomics can be used to support human health risk assessment.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectNanotoxicology
dc.subjectSystems Biology
dc.subjectToxicogenomics
dc.subjectToxicity Testing in the 21st Century
dc.titleUse of Systems Biology in Deciphering Mode of Action and Predicting Potentially Adverse Health Outcomes of Nanoparticle Exposure, Using Carbon Black as a Model
dc.typeThesis
dc.faculty.departmentBiologie / Biology
dc.contributor.supervisorWhite, Paul
dc.contributor.supervisorYauk, Carole
dc.embargo.termsimmediate
dc.degree.namePhD
dc.degree.leveldoctorate
dc.degree.disciplineSciences / Science
thesis.degree.namePhD
thesis.degree.levelDoctoral
thesis.degree.disciplineSciences / Science
uottawa.departmentBiologie / Biology
CollectionThèses, 2011 - // Theses, 2011 -

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