Identifying a Network of Brain Regions Involved in Aversion-Related Processing: A Cross-Species Translational Investigation

FieldValue
dc.contributor.authorHayes, Dave J.
dc.contributor.authorNorthoff, Georg
dc.date.accessioned2012-03-06T04:47:56Z
dc.date.available2012-03-06T04:47:56Z
dc.date.created2011
dc.date.issued2011
dc.identifier.urihttp://hdl.handle.net/10393/20729
dc.description.abstractThe ability to detect and respond appropriately to aversive stimuli is essential for all organisms, from fruit flies to humans. This suggests the existence of a core neural network which mediates aversion-related processing. Human imaging studies on aversion have highlighted the involvement of various cortical regions, such as the prefrontal cortex, while animal studies have focused largely on subcortical regions like the periaqueductal gray and hypothalamus. However, whether and how these regions form a core neural network of aversion remains unclear. To help determine this, a translational cross-species investigation in humans (i.e., meta-analysis) and other animals (i.e., systematic review of functional neuroanatomy) was performed. Our results highlighted the recruitment of the anterior cingulate cortex, the anterior insula, and the amygdala as well as other subcortical (e.g., thalamus, midbrain) and cortical (e.g., orbitofrontal) regions in both animals and humans. Importantly, involvement of these regions remained independent of sensory modality. This study provides evidence for a core neural network mediating aversion in both animals and humans. This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behavior can often be observed.
dc.language.isoen
dc.subjectmeta-analysis
dc.subjecttranslational
dc.subjectaversion
dc.subjectimaging
dc.subjectanimal models
dc.titleIdentifying a Network of Brain Regions Involved in Aversion-Related Processing: A Cross-Species Translational Investigation
dc.typeArticle
dc.identifier.doi10.3389/fnint.2011.00049
CollectionMédecine // Medicine
Publications en libre accès financées par uOttawa // uOttawa financed open access publications

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