Family History in the Assessment of Risk for Common Complex Diseases: Current State of Evidence

FieldValue
dc.contributor.authorHasanaj, Qendresa
dc.date.accessioned2012-02-08T16:30:53Z
dc.date.available2012-02-08T16:30:53Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/20682
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5462
dc.description.abstractFamily history (FH) is a risk factor for many diseases. Disease guidelines often include family history as important in assessing chronic disease risks, but the empirical evidence base to inform the routine use of family history in primary care in practice appears largely lacking. An environmental scan of how family history is represented in prevention guidelines for five conditions showed that, while family history is often included in guidelines, there is variation in the definition used, recommendation given and evidence cited. A dataset on cardiovascular health in women was analyzed to examine whether family history offers useful discrimination value above standard risk factors. Regression results showed that family history is an independent risk predictor for coronary heart disease which improves discrimination beyond classical clinical factors. However, the absolute amount of discriminatory ability alone or with other factors is moderate at best, raising issues regarding clinical utility.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectrisk assessment
dc.subjectfamily history
dc.subjectchronic diseases
dc.subjectcoronary heart disease
dc.subjectclinical discrimination factors
dc.titleFamily History in the Assessment of Risk for Common Complex Diseases: Current State of Evidence
dc.typeThesis
dc.faculty.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
dc.contributor.supervisorWilson, Brenda
dc.contributor.supervisorLittle, Julian
dc.embargo.termsimmediate
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
CollectionThèses, 2011 - // Theses, 2011 -

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