Hemaglobinopathy and Pregnancy Outcomes: A Historical Cohort Study

FieldValue
dc.contributor.authorLiu, Song
dc.date.accessioned2012-01-20T20:07:45Z
dc.date.available2012-01-20T20:07:45Z
dc.date.created2012
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10393/20621
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-5392
dc.description.abstractPregnancy in women with hemoglobinopathy has been associated with an increased risk of adverse pregnancy outcomes. We conducted a historical cohort study using Discharge Abstract Database for the fiscal year 1991-1992 through 2007-2008. We estimated the frequency of pregnant women with hemoglobinopathy and examined their associations with adverse pregnancy outcomes. Women with sickle cell disease are more likely to develop pre-eclampsia and preterm labor, and to undergo cesarean delivery than women with nutritional deficiency anemia, suggesting that there are other mechanisms beyond anemia that may be responsible for an increased risk of adverse pregnancy outcomes. The data suggested a synergistic effect of hemoglobinopathy and pre-eclampsia on preterm labor and cesarean delivery. Prediction models for pre-eclampsia, preterm labor and cesarean delivery were created and internally validated for women with hemoglobinopathy, with satisfactory discrimination and calibration.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectHemaglobinopathy
dc.subjectsickle cell disease
dc.subjectthalassemia
dc.subjectpregnancy outcomes
dc.subjectpre-eclampsia
dc.subjectpreterm labor
dc.subjectcesarean delivery
dc.titleHemaglobinopathy and Pregnancy Outcomes: A Historical Cohort Study
dc.typeThesis
dc.faculty.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
dc.contributor.supervisorChen, Yue
dc.contributor.supervisorLiu, Shiliang
dc.embargo.termsimmediate
dc.degree.nameMSc
dc.degree.levelmasters
dc.degree.disciplineMédecine / Medicine
thesis.degree.nameMSc
thesis.degree.levelMasters
thesis.degree.disciplineMédecine / Medicine
uottawa.departmentÉpidémiologie et médecine sociale / Epidemiology and Community Medicine
CollectionThèses, 2011 - // Theses, 2011 -

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