The Effects of Acute Running Induced Neuronal Activation on Cerebral GLUT1 and Vascular Plasticity

dc.contributor.authorLiang, Jacky
dc.description.abstractMorphologic and metabolic change is a known property of the adult brain. A number of behavioural tasks alter local cerebral blood flow and glucose utilisation. The expression of the glucose transporter 1 (GLUT1), which allows the entry of glucose to the brain, also has been shown to change in response to long-lasting neuronal activation. However, little is known about the effect of acute neuronal activation on GLUT1 expression. Using immunohistochemistry and Western blot, we investigated cerebral GLUT1 expression and vasculature density in mice undergoing a 48-hour voluntary wheel running period. The results showed that the striatum was the main region where GLUT1 protein was up-regulated: There was a trend for GLUT1 expression and blood vessels density to be associated with the distance run during the experiment. These results indicate that short-term increased neuronal activation is associated with rapid changes in glucose transport and possibly vascular remodelling.
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectneuronal plasticity
dc.subjectglucose transporter
dc.subjectWestern blot
dc.subjectcluster of differentiation 31
dc.subjectPlatelet endothelial cell adhesion molecule
dc.titleThe Effects of Acute Running Induced Neuronal Activation on Cerebral GLUT1 and Vascular Plasticity
dc.faculty.departmentPsychologie / Psychology
dc.contributor.supervisorMessier, Claude
dc.embargo.termsimmediate sociales / Social Sciences sociales / Social Sciences
uottawa.departmentPsychologie / Psychology
CollectionThèses, 2011 - // Theses, 2011 -