Effects of Selected Natural Health Products on Drug Metabolism: Implications for Pharmacovigilance

FieldValue
dc.contributor.authorLiu, Rui
dc.date.accessioned2011-03-10T15:28:36Z
dc.date.available2011-03-10T15:28:36Z
dc.date.created2011
dc.date.issued2011
dc.identifier.urihttp://hdl.handle.net/10393/19818
dc.identifier.urihttp://dx.doi.org/10.20381/ruor-4461
dc.description.abstractSeventeen Cree anti-diabetic herbal medicines and eight Traditional Chinese Medicines have been examined for their potential to cause interactions with drugs, which is considered as a major reason for adverse drug effects. Specifically, the effect of these natural health products was examined on major Phase I drug metabolism enzymes including cytochrome P450, human carboxylesterase-1 and flavin-containing monooxygenases. Several of these natural health products have the potential to cause adverse drug effect through the inhibition of major drug metabolism enzymes. The results indicated that 7 Cree medicines plant extracts inhibited CYP3A4 activity, and 3 of them have been proven to cause potent mechanism-based inactivation of CYP3A4. Seven of eight Traditional Chinese Medicines have been identified as strong CYP3A4 inhibitors; the ethanol extract of Goji has identified as a potent inhibitor for CYP2C9 and 2C19. Goji juice showed universal inhibitory effects on most of the tested enzymes except flavin-containing monooxygenases 3.
dc.language.isoen
dc.publisherUniversité d'Ottawa / University of Ottawa
dc.subjectCree Traditional Medicine
dc.subjectCytochrome P450
dc.subjectEnzyme Inhibition
dc.subjectFMO
dc.subjectHuman Carboxylesterase 1
dc.subjectMechanism Based Inactivation
dc.subjectMetabolic drug interaction
dc.subjectNatural Health Products
dc.subjectOseltamivir
dc.subjectTraditional Chinese Medicine
dc.subjectType 2 Diabetes
dc.titleEffects of Selected Natural Health Products on Drug Metabolism: Implications for Pharmacovigilance
dc.typeThesis
dc.faculty.departmentMédecine cellulaire et moléculaire / Cellular and Molecular Medicine
dc.contributor.supervisorFoster, Brian C.
dc.contributor.supervisorKrantis, Anthony
dc.embargo.termsimmediate
dc.degree.namemsc
dc.degree.levelmasters
dc.degree.disciplinemedicine
thesis.degree.namemsc
thesis.degree.levelMasters
thesis.degree.disciplinemedicine
uottawa.departmentMédecine cellulaire et moléculaire / Cellular and Molecular Medicine
CollectionThèses, 2011 - // Theses, 2011 -

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